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Veterinary Specialty Hospital - North County

Tolerability of Oral Paclitaxel in Cancer Bearing Dogs


Research Type

Ethos Discovery De Novo Study


Paclitaxel is a human chemotherapeutic that has demonstrated a broad spectrum of activity against several human and canine cancers. Previous formulations of paclitaxel have been poorly absorbed in dogs, limiting its therapeutic value. Oraxol is a novel oral formulation of paclitaxel that is combined with a second drug, Encequidar, which improves this issue of poor absorption. Preclinical studies have demonstrated safety in dogs, making Oraxol an intriguing choice for further study in cancer-bearing dogs. The data collected from this study will help to inform future studies in the treatment of canine hemangiosarcoma, a common and aggressive cancer in dogs.


  • Dogs diagnosed with cancer of any kind

  • Dogs weighing between 10kg (22lb) and 45kg (99lb)

  • Dogs who have not received chemotherapy within 14 days of study entry

  • Dogs with no significant kidney disease

  • Dogs with no significant liver disease


  • Massachusetts Veterinary Referral Hospital, Woburn, MA

  • Peak Veterinary Referral Center, Williston, VT

  • Pet Emergency & Specialty Center of Marin (PESCM), San Rafael, California

  • VERC, Honolulu, HI

  • Veterinary Specialty Hospital, Sorrento Valley, San Diego, CA

  • Veterinary Specialty Hospital, North County, San Marcos, CA

  • Wheat Ridge Animal Hospital, Wheat Ridge, CO

  • WVRC – Waukesha, Waukesha, WI